Thus, it was not surprising that the NLRP6 inflammasome was found to play a critical role in preventing chemical-induced colitis [dextran sodium sulfate (DSS) treatment] as Nlrp6−/− and ASC−/− mice display increased exacerbation of disease characterized by increased spontaneous intestinal hyperplasia, elevated inflammatory cell recruitment, increased weight loss and reduced survival (137). The gene discussed is NLRP6; the disease is colitis.