In addition to F. novicida, AIM2 is important for inflammasome activation during infection with Listeria monocytogenes, Mycobacterium tuberculosis, Porphyromonas gingivalis, Streptococcus pneumoniae, vaccinia virus, and mouse cytomegalovirus, but not S. typhimurium infection (35–39). This evidence concerns the gene AIM2 and infection.