RUNX3 and neoplasm: Introducing the independent gene aberrations significantly associated with early recurrence risk (losses of RUNX3, CDKNA2A, CACNA1G and IGF2) and controlling for the above mentioned molecular subtypes and age, gender, stage and tumor location, revealed a final model that included only RUNX3 and CDKN2A together with stage as predictors of early recurrence (Table 4).