Considering that the substitution therapy with MBL is now available and safe, the confirmation of the abovementioned association might provide the rationale for a controlled trial to evaluate the efficacy of early administration of MBL in the management of respiratory complications of NICU neonates with low MBL serum levels and/or genotypic MBL deficiency. Here, MBL2 is linked to hyperinsulinemic hypoglycemia, familial, 4.