In previous studies, there was correlation between obesity (BMI) and VO2max (r = −0.88, P < 0.05) in young subjects [26] and a strong positive correlation between the ratio of PPARG (splice variants y2/y1) mRNA and the BMI (r = 0.70, P < 0.001) in obese patients [27]. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.