We first demonstrated that curcumin, in vitro, has a role in the regulation of proliferation and apoptosis of MDA.MB231 cells. In vivo, we showed that curcumin inhibited tumor growth and angiogenesis in a heterotopic mouse model of breast cancer by influencing the expression of NF-κB-regulated gene products (cyclin D1, PECAM-1, and p65). This evidence concerns the gene PECAM1 and neoplasm.