In our study, we found that pretreatment with ghrelin could induce ADMSC proliferation, inhibit apoptosis, and increase VEGF secretion under H/SD injury in vitro; moreover, ghrelin could exert a protective effect on mesenchymal stem cells (ADMSCs) in the model of MI in the mouse heart, indicating that ghrelin may be a favorable factor in stem cell-based IHD therapy. This evidence concerns the gene GHRL and myocardial ischemia.