Interestingly, somatic CRBP-1 silencing, induced by inoculation of athymic mice with MTSV cells, an SV40-immortalized human mammary epithelial cell line, transfected with empty vector (MTSVvector) or CRBP-1 (MTSVCRBP-1), has shown to prevent tumor cells from taking up, storing, and using retinol in vivo [137]. Here, RBP1 is linked to neoplasm.