Downregulation or loss of CRBP-1 expression occurs in a series of tumors: breast, ovarian, endometrial, prostate, renal cancer, astrocytic gliomas [112, 121, 122], cervical cancer, larynx cancer, nasopharyngeal carcinoma, lymphoma, and gastrointestinal carcinomas [123]. The gene discussed is RBP1; the disease is digestive system carcinoma.