RBP1 and leiomyosarcoma: Accumulation of CRBP-1 in leiomyosarcoma likely supports the conversion of retinol into RA and its biological effects through RAREs induction, which influence the expression of many genes through the interaction with RAREs regions, inducing the increase of CRBP-1 expression in epithelioid SMCs as well as fibroblasts [29].