VCP and inclusion body myopathy with Paget disease of bone and frontotemporal dementia: Mutations in the gene encoding VCP lead to disruption of autophagy and have been shown to manifest within families as a phenotypically heterogeneous group of presentations including hereditary inclusion body myopathy (IBM), Paget's disease of the bone (PDB), and frontotemporal dementia (FTD), which are known collectively as IBMPFD [2].