Our data showed that the enhanced expression of TLR4 by LPS challenge was significantly downregulated with pretreatments of YJH at the doses of 170 and 340 mg/kg, which corresponded with the level changes of IκB α, NF-κB p65, and other proinflammatory cytokines, in ALI mice lung tissues. This evidence concerns the gene NFKB1 and acute respiratory distress syndrome.