Moreover because of insufficient insulin supply in these countries, disability due to obesity-related and type 2 diabetes will also increase due to arteriosclerosis, nephropathy and retinopathy.8 Yet another related health problem due to increasing prevalence of obesity will be the number of years that patients suffer from obesity-related morbidity and disability which would also increase significantly.8 The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.