IL18 and cardiovascular disorder: Previous studies have shown that C allele of IL-18-607A/C and G allele of IL-18-137C/G could affect the IL-18 higher transcription and its protein production.14,15 Previous studies have also shown that IL-18 gene polymorphisms are correlated with risk of cardiovascular disease.16,17 However, few studies have reported the association between IL-18 polymorphisms and risk of IS.