Recently, Rocha et al. reported that platelet response of ITP after eradication of H. pylori was associated with the imbalance correction of T-helper (Th) and T regulatory (Treg) cytokines.20 This result indicates that the immune responses to H. pylori infected patients with ITP are different, which may be due to the difference between H. pylori strains, e.g. CagA+ and CagA- strains. Here, S100A8 is linked to autoimmune thrombocytopenic purpura.