Studies have showed that postmenopausal women with coronary heart disease can benefit from estrogen replacement therapy.9 In early menopause, estrogen replacement therapy or estrogen-progestin combination therapy on postmenopausal women with CHD could reduce the level of LDL-C and increase the level of HDL-C.10 This effect of estrogen may act directly on the vessel wall by combining with the estrogen receptor to affect the deposition of lipids in the vessel wall. Here, ESR1 is linked to coronary artery disorder.