ESR1 and neoplasm: CAPS remained an independent prognostic marker in a Cox proportional multivariate analysis for RFS (HR = 3.6; p = 0.011), while nodal status (node-negative versus node-positive) (HR = 1.7; p = 0.22), tumor size (<20 mm versus ≥ 20 mm) (HR = 1.4; p = 0.43), age (HR = 1.0; p = 0.87), ER (HR = 0.88; p = 0.073) and PgR (HR = 0.96; p = 0.48) were not (Table 4).