NFKB1 and acute pancreatitis: In this study, we demonstrated (1) the renal injuries that were caused by the STC-induced acute pancreatitis were significantly improved by hydrogen-rich saline; (2) the mechanism by which hydrogen-rich saline attenuates acute renal injury was to reduce oxidative stress and inhibit activation of NF-κB by inhibiting IκB nitration and degradation; (3) hydrogen-rich saline downregulated the expression of “evil” inflammatory mediators and promote “angelic” inflammatory cytokine to produce.