NOS3 and rheumatoid arthritis: Moreover, some NOS variants, particularly the NOS2 Ser608Leu as well as the pentanucleotide microsatellite −2.5 kb (CCTTT)n and the NOS3 −786T>C, were associated with either increased nitrite/nitrate levels, total serum immunoglobulin E, and blood eosinophil levels or cytokines in various allergic/inflammatory/autoimmune disorders, including atopy, asthma, migraine, inflammatory bowel disease, or rheumatoid arthritis [16–20, 29–33].