In 20-week-old ZDF rats fed sitagliptin (10 mg/kg) for 6 weeks, significant decreases were noted in serum levels of high sensitivity C-reactive protein and IL-1β [9].This study evidenced that oral administration of sitagliptin can prevent abdominal aortic aneurysm formation in Ang II-infused apoE-/- mice, at least in part, by increasing of active GLP-1 level, decreasing of MMP-2 and MMP-9 production from infiltrated macrophage. This evidence concerns the gene GCG and abdominal aortic aneurysm.