Moreover, PAR4 mRNA was increased by 2.3 (2.0, 3.8) folds in 16 poor-differentiated tumors and by 0.9 (0.5, 1.2) folds in 22 well-/moderated- differentiated cancers (p = 0.001, Mann-Whitney U Text); TFF2 mRNA was increased by 2.2 (1.8, 5.8) folds in 16 poor- differentiated tumors and by 0.8 (0.3, 1.5) folds in 22 well-/moderated-differentiated cancers (p = 0.002, Mann-Whitney U Text) (Fig 2B). Here, F2RL3 is linked to cancer.