FHIT and gastric cancer: The protein and mRNA levels of FHIT were significantly lower in patients with H. pylori infection and without family histories of gastric cancer than those without H. pylori infection and family histories of gastric cancer (P<0.05; Figs 2 and 3), these levels were also significantly lower in patients with H. pylori infection when compared with those with no H. pylori infection (P<0.05; Figs 2 and 3).