FHIT and gastric cancer: The protein and mRNA levels of FHIT were significantly lower in patients with family histories of gastric cancer and without H. pylori infection than those without H. pylori infection and family histories of gastric cancer (P<0.05; Figs 2 and 3), and were also significantly lower in patients with family histories of gastric cancer when compared with those without family histories of gastric cancer (P<0.05; Figs 2 and 3).