ZNF146 and colorectal carcinoma: However, although the classical C2H2 zinc finger motif is the most abundant among all zinc finger protein classes [38], no further C2H2 motif zinc finger proteins were discovered as CRC-specific autoantigens among other 200 ZNF proteins deposited on the protein arrays, suggesting that the C2H2 motif may enhance the immunogenicity of the autoantigen without loosing the immunogenic uniqueness of the corresponding epitope.