Likewise, tissue inhibitor of metalloproteinase-1 (TIMP1; *p = 0.022), fibronectin-1 (*p = 0.013) and biglycan (*p = 0,014) were significantly up-regulated in BC−/EC+, while matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-3 and decorin were only slightly but not significantly up-regulated throughout the heart compared to BC+/EC+. This evidence concerns the gene TIMP1 and breast cancer.