KLK3 and cancer: Age (P < 0.001, OR = 1.076, 95% CI: 1.065–1.087), PSA (P < 0.001, OR = 1.213, 95% CI: 1.165–1.262), prostate volume (P < 0.001, OR = 0.959, 95% CI: 0.953–0.965), abnormal findings with hard nodules on digital rectal examination (P < 0.001, OR = 1.447, 95% CI: 1.158–1.810), and abnormal TRUS findings with suspicious hypoechoic lesions (P < 0.001, OR = 1.627, 95% CI: 1.311–2.019) were significantly associated with cancer detection on PBx in multivariate analysis (Table 2).