Recent genome-wide association studies evaluating the genetic determinants of adiponectin levels, including ADIPOQ, CDH13 and WDR11-FGFR2 gene variants, have reported considerable associations with various metabolic phenotypes, including insulin resistance, diabetes mellitus, metabolic syndrome, and cardiovascular disease [10, 14–16, 19]. Here, FGFR2 is linked to metabolic syndrome.