FOXP3 and neoplasm: Therefore, the present study extended previous studies using immunohistochemical tissue microarray analysis and image analysis applied to a large number of CRC cases (n = 767) to elucidate the prognostic significance according to type of individual T cell subset (CD8+, CD45RO+, and FOXP3+ phenotypes) densities and intratumoral subsite (tumor center or invasion front).