The failure of T cells from Ag+GILT-/-Tg mice to induce autoimmunity in addition to the similarly reduced recovery of these T cells following adoptive transfer irrespective of GILT expression in the recipient points to an intrinsic defect in T cells from Ag+GILT-/-Tg mice that ultimately impairs their ability to mediate autoimmunity and anti-tumor immunity. The gene discussed is RENBP; the disease is neoplasm.