The delayed onset of autoimmunity following transfer of T cells from Ag-GILT+/+Tg mice into GILT-/-RAG1-/- mice vs. RAG1-/- mice as well as the reduced recovery of TRP1-specific T cells following transfer into GILT-/-RAG1-/- mice highlights the importance of GILT expression in host APC’s for the efficient processing and presentation of TRP1. Here, RAG1 is linked to Autoimmunity.