TNF and glaucoma: TNF is a biomarker associated with RGC death in patients with glaucoma.[9] Meta-analysis of six studies showed that aqueous humor levels of TNF were higher in persons with OAG than in control samples.[27] While no prior study has shown definitively that bupropion reduces TNF levels in humans, Brustolim and coworkers postulated that this drug decreases TNF synthesis by increasing extracellular norepinephrine and dopamine.[28] The secondary beta-adrenergic and D1 dopaminergic stimulation increases intracellular cyclic adenosine monophosphate (cAMP) and suppresses TNF synthesis.