For instance, Shadick et al. [15] used C-reactive protein to predict the likelihood of RA, whereas Huizinga et al. [16] examined nine clinical variables (gender, age, localization of symptoms, morning stiffness, tender and swollen joint count, C-reactive protein, rheumatoid factor, and anti-CCP antibodies) to construct prediction rules. The gene discussed is CRP; the disease is rheumatoid arthritis.