Figure 1A shows the immunohistochemical expression of MCT1, MCT4, glucose transporter 1 (GLUT1), hexokinase 2 (HK2), lactate dehydrogenase 5 (LDH5), pyruvate dehydrogenase kinase 1 (PDK1), carbonic anhydrase IX (CAIX) and hypoxia‐inducible factor 1α (HIF‐1α) in benign prostate tissue (BT), prostatic intra‐epithelial neoplasia (PIN), localized prostate tumour tissue (LT) and metastatic tumour tissue (MT). This evidence concerns the gene HK2 and prostate intraepithelial neoplasia.