Thus, our finding that FOXC1 is overall highly expressed in pancreatic cancer cell lines and primary pancreatic cancer tissues, as well our finding that FOXC1 down-regulation has an inhibitory (anti-proliferative) effect on pancreatic cancer cell growth, supports the idea that FOXC1 likely acts as a proliferative factor in pancreatic cancer. The gene discussed is FOXC1; the disease is familial pancreatic carcinoma.