Similarly to TRIM26, ZBTB16 is involved in cell cycle regulation by encoding a transcriptional repressor that was identified in patients with acute promyelocytic leukemia [59], while mutations in mice have revealed that ZBTB16 also plays an important role in skeletal development and spermatogonial stem-cell maintenance [60, 61]. Here, ZBTB16 is linked to acute promyelocytic leukemia.