The major role of PTEN as a potent tumor suppressor relies on its function as a lipid phosphatase, dephosphorylating the 3’ position of phosphatidylinositol 3,4,5-trisphosphate (PIP3) to generate phosphatidylinositol 4,5-bisphosphate (PIP2), which directly antagonizes the oncogenic activity of PI3K [9,10]. Here, PTEN is linked to neoplasm.