Overall, YKL-40 tumor expression was observed in 47 (62%) cases, with a moderate or strong immunostaining localized within the cytoplasm of neoplastic cells (Fig 2A and 2B), while forty-three (56%) cases were positive for c-Met with a moderate or strong cytoplasmic reactivity (Fig 2A and 2C). The gene discussed is MET; the disease is neoplasm.