PLCD1 and Nail dystrophy: Leukonychia (NDNC3), characterized by white discoloration of the nails, is caused by an alteration in PLCD1 [4]; Anonychia/hyponychia (NDNC4, absence of hypoplasia of nails) due to an alteration in RSPO4 [5]; toenail dystrophy (NDNC8), caused by an alteration in COL7A1 [6] and onychodystrophy (NDNC10), associated with an alteration in FZD6 [7].