Taken together, previously unrecognized co-occurring deletion of CDKN1A and MAPK14 on 6p and amplification of KRAS on 12p, which encode for human cell transformation, together with deletion of TNF on 6p, and amplification of RAD51AP1 and ITPR2 on 12p, are correlated with a suppression of cell cycle arrest, senescence, and apoptosis, i.e., a tumor cell’s immortality, and a patient’s shorter survival time. This evidence concerns the gene CDKN1A and neoplasm.