One deletion (7p22.1-p21.3) contains the replication protein A3-encoding RPA3. The other (Xq21.31) contains the cytoplasmic poly(A)-binding protein 5-encoding PABPC5, and the sequence tag site DX214 adjacent to translocation breakpoints observed in premature ovarian failure [38]. This evidence concerns the gene RPA3 and primary ovarian failure.