ITPR2 and germ cell tumor: Two other consecutive segments (12p11.23) contain the inositol 1,4,5-trisphosphate receptor type 2-encoding ITPR2, and the asunder spermatogenesis regulator-encoding ASUN. ASUN was discovered in a screen of expressed sequence tags on 12p11-p12, which DNA amplification correlated with mRNA overexpression in four human testicular seminomas and one ovarian papillary serous adenocarcinoma cell line, exemplifying human germ cell tumors [36].