The role of ITGB3 in ovarian cancer has been implicated in a study by Kaur et al. in which over-expression of ITGB3 in SKOV3ip1 cells (cell line generated from ascites developed in nu/nu mouse by administering an intraperitoneal injection of SKOV3 cells) was found to be associated with decreased invasion, protease expression, as well as colony formation [41]. The gene discussed is ITGB3; the disease is ovarian cancer.