The involvement of activated PRKCZ in epidermal growth factor (EGF)-induced chemotaxis has also been examined in lung and breast cancer, and it was shown that PRKCZ is able to elicit a migration response of these cells by acting as a downstream mediator in the phosphatidylinositol 3-kinase (PI3K)/AKT pathway [6,7]. Here, EGF is linked to breast cancer.