PLA2G7 and autoimmune disease: In light of success in other models of macrophage mediated vascular inflammatory pathologies, albeit not in autoimmune disease, and given that tissue damage in uveitis is dependent upon macrophage infiltration and activation, we utilised Lp-PLA2 knockout (KO) mice and a specific Lp-PLA2 pharmacological inhibitor SB-435495 (referred to herein as Lp-PLA2deletion or inhibition respectively) to determine the role of Lp-PLA2 in autoimmune retinal inflammation.