Immunopositive Mb was detectable in the tumor cells with pores and in the activated immune cells in the HeLaX-E9s (Fig 6Ca and 6Cb); in the HeLaX-Ss, there were fewer tumor cells and immune cells with positive Mb immunoreactivity compared with the HeLaX-E9s (Fig 6Cc and 6Cd). Here, MB is linked to neoplasm.