The dying features of the respective regions of HeLaX-E9s (Fig 4I–4K) indicated apoptotic death of the perforated tumor cells expressing nNOS (Fig 4I), a cytotoxic appearance with remnants and/or apoptotic death in both iNOS- (Fig 4J) and eNOS-expressing regions (Fig 4K). This evidence concerns the gene NOS2 and neoplasm.