We have already reported that deprivation of the Epo signal by an anti-Epo antibody, soluble form of EpoR (sEpoR) capable of binding to Epo, or the EpoR antagonist EMP9 results in the destruction of the female malignancies described above through the induction of apoptosis and suppressed growth of tumor cells and the destruction of capillary endothelial cells [6, 13, 14, 36]. Here, EPO is linked to neoplasm.