PTPRC and Splenomegaly: Interestingly, similar to dcFADD-/- mice, mFADD-/- mice suffer from splenomegaly (Fig 1C) and lymphadenopathy (Fig 1E) with increased neutrophils (Ly6Clo CD11b+), inflammatory monocytes (Ly6ChiCD11b+), macrophages (CD11b+ F4/80+), B cells (B220+) and Ter119+ erythrocytes (Fig 1D, 1F, and 1G).