After adjusting for a family history of hypertension, physical exercise, family income and age at smoking initiation, the OR for hypertension of the smokers with the homozygous mutant CHRNA3 rs6495308 genotype was 1.26 (95% CI = 0.79–2.02), higher than that of the smokers with the homozygous wild-type genotype. This evidence concerns the gene CHRNA3 and hypertensive disorder.