Further, it is demonstrated that NP can exert an estrogen-like transcriptional activity on ER-positive breast cancer cells by binding to ER-α [24], and another study showed that BPA could bind to two ERs, ERα and ERβ, and be considered a selective ER modulator (SERM) that partially activates luciferase reporter in MCF-7 and HeLa cells. Here, ESR2 is linked to breast cancer.