Substitution of the 4′-hydroxyl group of moscatilin (4,4′-dihydroxy-3,3′,5′-trimethoxybibenzyl) with a methoxy group led to the synthesis of MT-4 (Fig 1A), which was the most effective derivative against ovarian cancer cell, A2780, with a GI50 of 0.04 μM. The gene discussed is MT4; the disease is ovarian cancer.