Meng et al. [14] studied only rectal cancer tissue and found a prominent heterogeneity in the expression of SATB1 mRNA since 45/93 patients showed increased and 48/93 decreased levels of SATB1 transcripts while the average level of SATB1 mRNA in tumor tissue was statistically higher than that in unchanged mucosa. The gene discussed is SATB1; the disease is rectal cancer.