The intensity of cytoplasmic SATB1 expression was significantly higher in cancer cells as compared to its expression in enterocytes, whether all CRC (IRS 1.14 ± 0.21 vs. 0.2 ± 0.13; P < 0.01; Fig. 4b) or only paired samples (IRS 1.13 ± 0.33 vs. 0.2 ± 0.13; P < 0.05) were analyzed. Here, SATB1 is linked to cancer.