MYC and monoclonal gammopathy: The study of Zhou et al. indicated that miR-17-5p exhibits a high expression level in myeloma cells and it may participate in the induction of p21Waf1/Cip1 expression, which relevant to the cell-cycle arrest process [46]. MYC has been reported to play a causal role in the progression of monoclonal gammopathy to MM [47]. EPC1, which interacts with miR-335 in the miRNA-mRNA regulatory network, has been shown to participate in growth regulation and has been suggested to be involved in a MYC-centered regulatory network [48].