It has been reported that tyrosine phosphorylation of CCDC50 is important for inhibition of the NFkB-mediated apoptotic pathway [66] and CCDC50 is required for survival in mantle cell lymphoma (MCL) and CLL cells [67]. KAT5 was another active gene: Zhao et al. [68] demonstrated that KAT5 negatively modulated c-Myb transcriptional activity by recruiting histone deacetylases in human hematopoietic cells. The gene discussed is MYB; the disease is B-cell chronic lymphocytic leukemia.