Another experimentally verified target of tumor suppressor microRNAs miR-143 and miR-145 is the cellular gene ERK5 (also known as MAPK7) a mitogen-activated protein kinase (MAPK) regulated by a wide range of mitogens and by cell stress, which promotes cell growth and proliferation in response to tyrosine kinase signaling [44]. This evidence concerns the gene MAPK7 and neoplasm.