Furthermore, Fabbri recently demonstrated that miR-21 and -29a secreted by tumor cells via exosomes could bind to toll-like receptor (TLR) 7/8 and activate these receptors on immune cells, leading to TLR-mediated NF-κB activation and secretion of prometastatic inflammatory cytokines that may ultimately lead to tumor growth and metastasis [70]. This evidence concerns the gene NFKB1 and neoplasm.