Regarding the difference between class IV and class V, no statistical difference was found in proteinuria, serum albumin, and cholesterol levels in this study, suggesting that all clinical features of nephrotic syndrome may be unimportant to define LN class IV and class V, whereas significant differences were observed in nephritic parameters including microscopic hematuria, anemia, high blood pressure, and impaired renal function between LN classes V and IV in initial biopsy finding. This evidence concerns the gene ALB and nephrotic syndrome.