Another study by Harmankaya et al. was done on 25 hypertensive type 2 diabetic patients with persistent microalbuminuria and normal renal function under treatment with combining pentoxifylline with an angiotensin converting enzyme inhibitor, lisinopril, on urinary albumin excretion compared with those obtained in a control group of 25 type 2 diabetic patients treated with lisinopril only and reporting a significant reduction in urinary albumin excretion in pentoxifylline group [32]. This evidence concerns the gene ACE and type 2 diabetes mellitus.