Not only a high fat diet, but other nutritional components may impact on developmental origin of cancer, since it was shown in rats that dietary protein type (soy protein isolate versus casein) during pregnancy had different effects on azoxymethane-induced colon tumor number and colon tissue gene expression, as well as serum IGF-I and testosterone levels in the offspring as adults [74]. This evidence concerns the gene IGF1 and colonic neoplasm.