Other intriguing possibilities of a relationship between APC and blood glucose levels come from data showing that the Wnt signaling pathway, which is as an important modulator of adipocyte differentiation [61, 62], also influences endocrine pancreas development and modulates mature β-cell functions, including insulin secretion, survival and proliferation, and thereby may be involved in the pathogenesis of diabetes [63]. This evidence concerns the gene INS and diabetes mellitus.