A shared mechanism which can suggest these association are role of 5-HT2 and 5-HT3.18-24 Some trials showed that anti receptors of 5-HT2 and 5-HT3 such as mirtazapine can be recommended as therapeutic agents for sexual dysfunction.25,26 To our knowledge there are not sufficient studies that examined the association of headache characteristics and sexual dysfunction. Here, HTR3A is linked to sexual dysfunction.