This disorder has been associated with mutation of CSTB, a gene encoding cystatin B protein responsible for reducing the activity of cathepsins enzymes (protease)58 and is inherited in an autosomal recessive (AR) pattern.59 Furthermore, different type of gene mutations including CHRNA4 gene (frontal lobe epilepsy) have been reported in different populations.49,50,60 It seems necessary to identify specific mutations in distinct population to provide better genetic counseling for epilepsy.21 This evidence concerns the gene CSTB and epilepsy.